The match began with Medeama SC showing great intent, taking control of the proceedings in the opening fifteen minutes and effectively neutralizing the threat posed by the Congolese giants.

The Ghanaian side looked comfortable on the ball and created several promising opportunities to break the deadlock. One of the best chances for the hosts fell to Dominic Amponsah, whose close-range effort was brilliantly thwarted by the TP Mazembe goalkeeper, Marc Diouf.

At the other end, Medeama’s shot-stopper Felix Kyei was equally impressive, making a spectacular save in the 43rd minute to deny Josue Kazema and ensure the first half ended goalless. Before the match, the Medeama Communications Director had boldly stated, "We are not scared of TP Mazembe," and for the majority of the game, the players played with that exact level of fearlessness. The second half continued in a similar fashion, with both teams searching for an opening, and Medeama’s Emmanuel Annor seeing his 64th-minute strike saved once again by the resilient Diouf. Just as the contest seemed destined for a goalless draw, the narrative shifted dramatically in the 86th minute.

A swift counter-attack by the visitors caught the Medeama defense exposed, allowing substitute Lise Ntumba Nyembo to find the back of the net and silence the Tarkwa crowd. This late strike proved to be the decisive blow, leaving Medeama with a narrow but painful 1-0 defeat on home soil. While the 1-0 loss is a significant setback, the Mauve and Yellows proved they can compete with the best on the continent.

They now face a formidable challenge as they travel to Lubumbashi for the return leg next week, where they must overturn this deficit to keep their CAF Champions League dreams alive. The journey is far from over, but a spirited performance away from home will be essential to progress to the next stage.